Insulin resistance primarily disrupts the uptake of which nutrient?

Insulin resistance primarily disrupts the uptake of glucose. In healthy metabolism, insulin facilitates the transport of glucose from the bloodstream into cells, particularly muscle and fat cells, where it can be utilized for energy or stored for later use. When insulin resistance occurs, the body's cells become less responsive to insulin, resulting in impaired glucose uptake. This leads to elevated levels of glucose in the bloodstream, a hallmark of conditions such as prediabetes and type 2 diabetes.

The other nutrients—proteins, fats, and vitamins—are not primarily affected by insulin in the same manner that glucose is. While insulin does play a role in the metabolism of fats and proteins, its central function in glucose regulation makes the disruption of glucose uptake the key focus in the context of insulin resistance. Thus, glucose stands out as the nutrient most significantly impacted by this condition, highlighting the crucial role of insulin in glucose metabolism and the detrimental effects that insulin resistance can have on this process.