What is the correct order of molecules in the lipogenesis of triglycerides starting with glucose?

The correct order of molecules in the lipogenesis of triglycerides starting with glucose is significant because it reflects the metabolic pathway through which carbohydrates are converted into fatty acids and then stored as triglycerides.

Starting with glucose, the first step in this process is glycolysis, where glucose is broken down into pyruvate. This pyruvate then enters the mitochondria, where it undergoes decarboxylation to form acetyl-CoA. Acetyl-CoA serves as a building block for fatty acid synthesis.

Once acetyl-CoA is available, it is converted into fatty acids through a series of reactions known as fatty acid synthesis. These fatty acids can then be assembled with glycerol to form triglycerides, which are the main form of stored fat in the body.

This sequence—glucose transforming into pyruvate, then into acetyl-CoA, followed by fatty acids and finally forming triglycerides—shows the detailed flow of metabolites during the lipogenesis pathway. This understanding is critical for comprehending how energy from carbohydrates is stored in the form of fats within the body.