Which of the following is a risk factor for developing insulin resistance?

Obesity is a significant risk factor for developing insulin resistance due to its impact on the body's metabolic processes. When excessive fat accumulates, especially around the abdomen, it can interfere with the normal functioning of insulin. This interference occurs because fat cells can release certain hormones and inflammatory substances that disrupt insulin signaling, making it less effective. Consequently, the body's ability to use insulin to facilitate glucose uptake by cells diminishes, leading to higher blood sugar levels and increased insulin resistance over time.

In contrast, regular physical activity contributes to improved insulin sensitivity, while high dietary fiber intake supports better blood sugar control by slowing glucose absorption. Low sugar consumption generally promotes better metabolic health and reduces the risk of insulin resistance, as high sugar intake, especially from refined sources, can exacerbate weight gain and the related metabolic disturbances. Understanding the role of obesity in metabolic health highlights the importance of maintaining a healthy weight through a balanced lifestyle to mitigate the risk of insulin resistance.